Metronidazole has shown evidence of mutagenic activity in various in vitro bacterial assay devices. Furthermore, a dose-response increase in the frequency of micronuclei was observed in mice just after intraperitoneal injections and a rise in chromosome aberrations happen to be claimed in individuals with Crohn's disorder who ended up addressed with 200-1200 mg/working day of metronidazole for 1 to 24 months.
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METROGEL is contraindicated in patients with a background of hypersensitivity to metronidazole or to another component from the formulation.
The incidence of individual adverse reactions were not drastically distinct concerning The 2 regimens. Except if percentages are otherwise stipulated, the incidence of individual adverse reactions listed below was lower than 1%:
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Various extended-time period oral scientific tests inside the rat have demonstrated statistically important improves in mammary and hepatic tumors at doses >885 mg/m²/working day.
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No fetotoxicity was noticed soon after oral metronida-zole in rats or mice. Even so, mainly because animal jnetoto reproduction scientific studies will not be always predictive of human reaction and given that oral metron-idazole has been revealed for being a carcinogen in certain rodents, this drug should be utilised during pregnancy only if Obviously necessary.
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It's not at jnetoto all acknowledged irrespective of whether metronidazole is existing in human milk following topical administration. Published literature experiences the presence of metronidazole in human milk right after oral administration.
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